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Influence of abiraterone acetate on circulating neuromediators in chemotherapy-naïve castration-resistant prostate cancer.
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Quality of life was assessed with self-administered patient questionnaires on pain, social functioning, emotional well being, vitality, activity limitation, bed disability, overall health, physical capacity, general symptoms, and treatment related symptoms.
LNCaP cells were grown on coverslips in steroid hormone-depleted medium ( A) and then stimulated for 10 min ( B and D) or 2 h ( Cand E) with 10 n m DHT ( B and C) or 10 μ m bicalutamide ( D and E).
Zytiga (abiraterone) works by reducing androgen production in the body.
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Androgen withdrawal causes a retardation of prostate cell growth, thought to be from programmed cell death and ischemic injury from anoxia.
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