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Ya que la edad de total osificación de los huesos varía de individuo a individuo (17-20 años para las extremidades superiores, 18-23 años para las extremidades inferiores) y debido que muchos son prescritos Accutane (isotretinoína) a finales de la adolescencia, cuando el crecimiento sigue ocurriendo, pero ha empezado a desacelerarse, existe un riesgo de una zona gris con gente siendo afectada sin tener conocimiento de ello.
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